Biochemical and ultrastructural studies induced by phanquone on Entamoeba histolytica NIH-200.
Artigo
em Inglês
| IMSEAR
| ID: sea-112987
ABSTRACT
The action of phanquone on the incorporation of (14C)1-DL-valine and (14C)-8-adenine in TCA insoluble fractions of Entamoeba histolytica was examined as indices of RNA and protein synthesis respectively. The former was found to show greater sensitivity to the drug in terms of the effect manifested in the dose response curves for these parameters. Electron microscopic investigations with increasing concentrations of the drug demonstrated progressive vacuolization with concomitant dissolution of ribosomal helices. The drug had no significant effect on nucleus and plasma membrane even at concentration as high as 200 micrograms/ml.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fenantrolinas
/
RNA Ribossômico
/
Microscopia Eletrônica
/
Entamoeba histolytica
/
Amebicidas
/
Histocitoquímica
/
Animais
Idioma:
Inglês
Ano de publicação:
1991
Tipo de documento:
Artigo
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