Responses of serum calcium and inorganic phosphate levels, parathyroid gland and C cells of Rattus norvegicus to heptachlor administration.
J Environ Biol
;
2004 Jan; 25(1): 75-80
Artigo
em Inglês
| IMSEAR
| ID: sea-113186
ABSTRACT
Intramuscular administration of two doses 0.50 LD50 (14.70 mg/kg b w) and 0.75 LD50 (22.30 mg/kg b w) of heptachlor in Rattus norvegicus for 14 days induced significant hypocalcemia without altering serum inorganic phosphate value. Parathyroid chief cells of the experimental rats exhibited degranulation, vacuolation, loss of secretory granules and lipid droplets, reduction in chromatin, and degenerative changes in endoplasmic reticulum and cristae of the mitochondria. Not much of histological and ultrastructural changes could be seen in C cells of the heptachlor treated rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Glândulas Paratireoides
/
Fosfatos
/
Ratos
/
Poluentes do Solo
/
Masculino
/
Cromatina
/
Cálcio
/
Grânulos Citoplasmáticos
/
Retículo Endoplasmático
/
Complexo de Golgi
Idioma:
Inglês
Revista:
J Environ Biol
Ano de publicação:
2004
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS