Metabolic dysregulation and inhibition of spermatogenesis by gibberellic acid in rat testicular cells.
J Environ Biol
;
2005 Jul; 26(3): 567-9
Artigo
em Inglês
| IMSEAR
| ID: sea-113274
ABSTRACT
Enzymatic and histological change in the testicular cells of rats treated orally and intradermally for 45 days with gibberellic acid (GBA) in independent studies is reported. Assay of hexokinase (HK), acid phosphatase (AcP) and alkaline phosphatase (AkP) in rat testicular tissue homogenate preparations yielded results that suggested changes in these enzyme activities relative to their respective controls. Histological studies showed loss of germ cells, derangement of the germinal cells, and reduction in the size of the seminiferous tubules and dystrophy of Leydig cells. More importantly decreased sperm count in the lumen was observed. A dysregulatory role is thus established for GBA in rat testicular cell function. This compound may serve as an inhibitor of testicular cell function.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Espermatogênese
/
Testículo
/
Extratos de Tecidos
/
Fosfatase Ácida
/
Masculino
/
Fosfatase Alcalina
/
Giberelinas
/
Hexoquinase
/
Animais
Idioma:
Inglês
Revista:
J Environ Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
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