Gender differences in the metabolism of benzene, toluene and trichloroethylene in rat with special reference to certain biochemical parameters.
J Environ Biol
;
2003 Apr; 24(2): 135-40
Artigo
em Inglês
| IMSEAR
| ID: sea-113338
ABSTRACT
Metabolites viz. phenol, hippuric acid and total trichloro compounds of benzene, toluene and trichloroethylene respectively were estimated in the urine samples of male and female rats after exposure for a period of 30 days. The results exhibited higher metabolism in female rats than the male rats. Their metabolism might be regulated by cytochrome P450 isozymes in a gender specific manner. However, sex differences in the activity of glutathione-S-transferases of the liver have also been found to determine their toxicity. Results have been discussed with quantitative profiles of other enzymes established in the liver of male and female rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Solventes
/
Tolueno
/
Tricloroetileno
/
Benzeno
/
Feminino
/
Masculino
/
Fatores Sexuais
/
Ratos Wistar
/
Sistema Enzimático do Citocromo P-450
Idioma:
Inglês
Revista:
J Environ Biol
Ano de publicação:
2003
Tipo de documento:
Artigo
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