Antigenotoxic effect of allicin against methyl methanesulphonate induced genotoxic damage.
J Environ Biol
;
2005 Jul; 26(3): 547-50
Artigo
em Inglês
| IMSEAR
| ID: sea-113348
ABSTRACT
Allicin, one of the sulfur compounds especially thiosulphonates of garlic (Allium sativum), possesses antioxidant and thioldisulphide exchange activity and is also shown to cause a variety of actions potentially useful for human health. In this investigation we determined its antigenotoxic potential using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) induced by methyl methanesulphonate (MMS) as genotoxic end points both in the presence as well as absence of rat liver microsomal activation system (S9 mix) in cultured human lymphocytes. We tested the effect of 5, 10 and 20 microM of allicin on the damage exerted by 60 microM of MMS. The levels of CAs and SCEs were lowered suggesting an antigenotoxic role of allicin against genotoxic damage both in the presence as well as absence of metabolic activation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Recombinação Genética
/
Ácidos Sulfínicos
/
Humanos
/
Microssomos Hepáticos
/
Linfócitos
/
Aberrações Cromossômicas
/
Relação Dose-Resposta a Droga
/
Animais
/
Metanossulfonato de Metila
Idioma:
Inglês
Revista:
J Environ Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
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