Toxicity of Nerium oleander leaf extract in mice.
J Environ Biol
;
2002 Jul; 23(3): 231-7
Artigo
em Inglês
| IMSEAR
| ID: sea-113573
ABSTRACT
Non-lethal dose of 70% ethanol extract of the Nerium oleander dry leaves (1000 mg/kg body weight) was subcutaneously injected into male and female mice once a week for 9 weeks (total 10 doses). One day after the last injection, final body weight gain (relative percentage to the initial body weight) had a tendency, in both males and females, towards depression suggesting a metabolic insult at other sites than those involved in myocardial function. Multiple exposure of the mice to the specified dose failed to express a significant influence on blood parameters (WBC, RBC, Hb, HCT, PLT) as well as myocardium. On the other hand, a lethal dose (4000 mg/kg body weight) was capable of inducing progressive changes in myocardial electrical activity ending up in cardiac arrest. The electrocardiogram abnormalities could be brought about by the expected Na+, K(+)-ATPase inhibition by the cardiac glycosides (cardenolides) content of the lethal dose.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Peso Corporal
/
Feminino
/
Masculino
/
Extratos Vegetais
/
Folhas de Planta
/
Nerium
/
Relação Dose-Resposta a Droga
/
Eletrocardiografia
/
Coração
/
Parada Cardíaca
Idioma:
Inglês
Revista:
J Environ Biol
Ano de publicação:
2002
Tipo de documento:
Artigo
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