Monitoring of cellular enzymes in the serum of electroplating workers at Coimbatore.
J Environ Biol
;
2007 Apr; 28(2): 287-90
Artigo
em Inglês
| IMSEAR
| ID: sea-113731
ABSTRACT
Chromium compounds are potent toxic and carcinogenic substances. With respect to toxicity, hepatic and renal toxicity have been reported both in workers and in animals exposed to chromium (VI). Chromium (VI) compounds induces DNA damage in vivo and in cultured cells as well as the cytotoxicity evaluated by the leakage of lactate dehydrogenase. The present study reports the cytotoxicity of chrome platers who are employed from 8 to 25 years in electroplating industries at Coimbatore, Tamilnadu. Blood samples were collected and estimated for glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and total protein in the serum. The study revealed that there is a significant elevation in the level of LDH, ALP, CPK and transaminases and a decrease in total protein in serum. The results of the study suggests that chromium (VI), a hepatotoxic chemical may perhaps damage the plasma membrane resulting in leakage of enzymes in to the serum of chromeplaters.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Aspartato Aminotransferases
/
Feminino
/
Humanos
/
Masculino
/
Biomarcadores
/
Cromo
/
Exposição Ocupacional
/
Adulto
/
Creatina Quinase
/
Alanina Transaminase
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
J Environ Biol
Ano de publicação:
2007
Tipo de documento:
Artigo
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