Acute toxicity effect of the venom of the marine snail, Conus zeylanicus.
J Environ Biol
;
2007 Oct; 28(4): 825-8
Artigo
em Inglês
| IMSEAR
| ID: sea-113739
ABSTRACT
Acute toxicity of the venom of Conus zeylanicus was studied to evaluate its risk and toxic factors in view of human safety The lethality of the crude venom (LD50 -60 mg/kg via i.p.) in mice was associated with increased heart rate and strong muscular hind limb paralysis, skeletal muscle paralysis, dyspnea, loss of spontaneous activity followed by respiratory failure. The effect on vital tissues revealed liver tissues were disrupted with hemorrhagic necrosis and the lung showed the pathogenic changes of diffused inflammation of the parenchyma and obliteration of the alveolar space. In brain, edema was observed throughout the parenchyma and the kidney shows the tubules with cloudyswelling of the lining cells and the parenchyma inflammation and few inflammatory cells infiltration.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Caramujo Conus
/
Dose Letal Mediana
/
Animais
/
Toxinas Marinhas
/
Camundongos
Idioma:
Inglês
Revista:
J Environ Biol
Ano de publicação:
2007
Tipo de documento:
Artigo
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