Pre-administration of beta-carotene protects tissue glutathione and lipid peroxidation status following exposure to gamma radiation.
J Environ Biol
;
2003 Oct; 24(4): 369-72
Artigo
em Inglês
| IMSEAR
| ID: sea-113821
ABSTRACT
The present study has been aimed to investigate the protective effect of beta-carotene against radiation-induced oxidative stress in mice tissues using lipid peroxidation and glutathione (GSH) as end points. Fourteen days oral priming administration of beta-carotene (35 mg/kg body weight) followed by an acute dose of gamma radiation (5 Gy) inhibited the augmented level of thiobarbituric acid reactive substance (TBARS) and a statistically significant protection against GSH depletion. Results evaluated from this study clearly indicate the antioxidative property of beta-carotene against gamma radiation, which is suggestive of free radical scavenging and singlet oxygen quenching.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Baço
/
Testículo
/
Encéfalo
/
Masculino
/
Peroxidação de Lipídeos
/
Substâncias Reativas com Ácido Tiobarbitúrico
/
Beta Caroteno
/
Raios gama
/
Glutationa
/
Rim
Idioma:
Inglês
Revista:
J Environ Biol
Ano de publicação:
2003
Tipo de documento:
Artigo
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