Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro.
J Environ Biol
;
2007 Apr; 28(2): 279-82
Artigo
em Inglês
| IMSEAR
| ID: sea-113879
ABSTRACT
Antioxidants and plant products are reported to reduce the genotoxic damage of steroids. In our present study we have tested different dosages of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in the presence of S9 mix. Treatments with nordihydroguaiaretic acid (NDGA) results in the reduction of the genotoxic damage. A significant decrease was observed at all the tested doses of NDGA in sister chromatic exchanges of number of abnormal cells. The results suggest a protective role of NDGA against the genotoxic damage.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Troca de Cromátide Irmã
/
Dano ao DNA
/
Masoprocol
/
Feminino
/
Humanos
/
Linfócitos
/
Células Cultivadas
/
Aberrações Cromossômicas
/
Anticoncepcionais Orais Sintéticos
/
Substâncias Protetoras
Idioma:
Inglês
Revista:
J Environ Biol
Ano de publicação:
2007
Tipo de documento:
Artigo
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