Accelerated molecular evolution of insect orthologues of ERG28/C14orf1: a link with ecdysteroid metabolism?
Artigo
em Inglês
| IMSEAR
| ID: sea-114301
ABSTRACT
We have analysed the evolution of ERG28/C14orf1, a gene coding for a protein involved in sterol biosynthesis. While primary sequence of the protein is well conserved in all organisms able to synthesize sterols de novo, strong divergence is noticed in insects, which are cholesterol auxotrophs. In spite of this virtual acceleration, our analysis suggests that the insect orthologues are evolving today at rates similar to those of the remaining members of the family. A plausible way to explain this acceleration and subsequent stabilization is that Erg28 plays a role in at least two different pathways. Discontinuation of the cholesterogenesis pathway in insects allowed the protein to evolve as much as the function in the other pathway was not compromised.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Filogenia
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Plantas
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Saccharomyces cerevisiae
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Schizosaccharomyces
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Bombyx
/
Software
/
Humanos
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Íntrons
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Proteínas
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Funções Verossimilhança
Idioma:
Inglês
Ano de publicação:
2001
Tipo de documento:
Artigo
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