Low dose 'Sprinkles'-- an innovative approach to treat iron deficiency anemia in infants and young children.
Indian Pediatr
;
2007 Feb; 44(2): 91-100
Artigo
em Inglês
| IMSEAR
| ID: sea-11437
ABSTRACT
Iron supplementation programs using pediatric tablets or drops have not been successful in the control of anemia amongst infants and children in India. Sprinkles is an innovative multi-micronutrient home fortification strategy to control iron deficiency and anemia. OBJECTIVE:
We aimed to determine the hematologic response to different doses and forms of iron in Sprinkles and iron drops.SETTING:
Twenty two villages of Vadu Rural Health Program, KEM Hospital, Pune.DESIGN:
Double blind clustered randomized community-based trial.SUBJECTS:
Children (n=432) aged 6 to 18 mo age with Hb between 70 to 100 g/L were enrolled.METHODS:
Selected villages were randomized into 5 groups Sprinkles 12.5, 20 or 30 mg ferrous fumarate, Sprinkles 20 mg micronized ferric pyrophosphate or drops 20 mg ferrous glycine sulphate (DROPS) for 8 weeks. Household socio-demographic information was collected at baseline. Side effects and compliance were monitored through weekly visits. Hemoglobin was estimated at baseline, 3 and 8 weeks. Ferritin was assessed at baseline and 8 weeks.RESULTS:
Baseline characteristics were similar across all groups. Hemoglobin increased significantly (P<0.0001) in all groups at 8 weeks with no difference between groups. Ferritin increased (P<0.0001) significantly in all groups with no difference across the groups. Compliance (overall range 42 to 62 %) was lowest for DROPS. Side effects were significantly higher among DROPS compared to Sprinkles (p>0.05).CONCLUSIONS:
Sprinkles 12.5 mg FF dose is as efficacious as higher doses of iron in Sprinkles or DROPS in increasing hemoglobin. Sprinkles FF 12.5 mg is recommended as it has fewer reported side effects and better compliance compared to DROPS.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fatores Socioeconômicos
/
Humanos
/
Hemoglobinas
/
Método Duplo-Cego
/
Anemia Ferropriva
/
Suplementos Nutricionais
/
Formas de Dosagem
/
Ferritinas
/
Lactente
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2007
Tipo de documento:
Artigo
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