Citrobacter freundii infection in glutaric aciduria type 1: adding insult to injury.
J Postgrad Med
;
2008 Jan-Mar; 54(1): 35-6
Artigo
em Inglês
| IMSEAR
| ID: sea-115253
ABSTRACT
Glutaric aciduria type 1 (GA1) is an inborn error of organic acid metabolism, where the brain is the principal organ affected with exposure to toxic metabolic product, 3-hydroxyglutaric acid (3-OHGA). A 2-year-old boy with GA1 and delayed developmental milestones had an acute neurological crisis leading to massive brain abscess with Citrobacter freundi infection, a rare cause of neonatal meningitis and often associated with brain abscess. Both 3-OHGA and C. freundii can damage the blood-brain barrier and can cause significant trauma which demands immediate and appropriate management. Encephalopathic manifestations of GA1 may consequently increase the risk of meningeal infection and it has not been previously documented.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Abscesso Encefálico
/
Humanos
/
Masculino
/
Pré-Escolar
/
Citrobacter freundii
/
Encefalopatias Metabólicas Congênitas
/
Diagnóstico Diferencial
/
Infecções por Enterobacteriaceae
/
Deficiência Múltipla de Acil Coenzima A Desidrogenase
/
Glutaratos
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Revista:
J Postgrad Med
Ano de publicação:
2008
Tipo de documento:
Artigo
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