A six-hour extrapolated sampling strategy for monitoring mycophenolic acid in renal transplant patients in the Indian subcontinent.
J Postgrad Med
;
2006 Oct-Dec; 52(4): 248-52
Artigo
em Inglês
| IMSEAR
| ID: sea-115574
ABSTRACT
BACKGROUND:
Therapeutic drug monitoring for mycophenolic acid (MPA) is increasingly being advocated. The present therapeutic range relates to the 12-hour area under the serum concentration time profile (AUC).However, this is a cumbersome, tedious, cost restricting procedure. Is it possible to reduce this sampling period?AIM:
To compare the AUC from a reduced sampling strategy with the full 12-hour profile for MPA. SETTINGS ANDDESIGN:
Clinical Pharmacology Unit of a tertiary care hospital in South India. Retrospective, paired data. MATERIALS ANDMETHODS:
Thirty-four 12-hour profiles from post-renal transplant patients on Cellcept were evaluated. Profiles were grouped according to steroid and immunosuppressant co-medication and the time after transplant. MPA was estimated by high performance liquid chromatography with UV detection. From the 12-hour profiles the AUC up to only six hours was calculated by the trapezoidal rule and a correction factor applied. These two AUCs were then compared. STATISTICALANALYSIS:
Linear regression, intra-class correlations (ICC) and a two-tailed paired t-test were applied to the data.RESULTS:
Comparing the 12-hour AUC with the paired 6-hour extrapolated AUC, the ICC and linear regression(r2) were very good for all three groups. No statistical difference was found by a two-tailed paired t-test. No bias was seen with a Bland Altman plot or by calculation.CONCLUSION:
For patients on Cellcept with prednisolone +/- cyclosporine the 6-hour corrected is an accurate measure of the full 12-hour AUC.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fatores de Tempo
/
Humanos
/
Adolescente
/
Transplante de Rim
/
Monitoramento de Medicamentos
/
Adulto
/
Área Sob a Curva
/
Imunossupressores
/
Índia
/
Pessoa de Meia-Idade
Tipo de estudo:
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
J Postgrad Med
Ano de publicação:
2006
Tipo de documento:
Artigo
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