Life-threatening overdose with lamotrigine, citalopram, and chlorpheniramine.
J Postgrad Med
;
2008 Oct-Dec; 54(4): 316-7
Artigo
em Inglês
| IMSEAR
| ID: sea-115742
ABSTRACT
Lamotrigine is a commonly used agent for seizure control in epilepsy. There are limited data on the adverse effects of lamotrigine in overdose. We report a number of serious side-effects associated with a large overdose of lamotrigine. A 23-year-old female presented to the emergency department after taking an intentional overdose of 9.2 g of lamotrigine, 56 mg of chlorpheniramine, and 220 mg of citalopram. On admission, she had a reduced level of consciousness and electrocardiographic abnormalities; a widened QRS and a prolonged corrected QT (QTc) interval. Prompt treatment with early intubation, along with the use of magnesium for cardioprotection and administration of sodium bicarbonate may have aided in a quick recovery with a short intensive care stay and good outcome.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Intoxicação
/
Triazinas
/
Síndrome do QT Longo
/
Feminino
/
Humanos
/
Citalopram
/
Clorfeniramina
/
Administração Oral
/
Resultado do Tratamento
/
Bicarbonato de Sódio
Idioma:
Inglês
Revista:
J Postgrad Med
Ano de publicação:
2008
Tipo de documento:
Artigo
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