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Assessment of left ventricular systolic and diastolic function in juvenile rheumatoid arthritis.
J Postgrad Med ; 2004 Oct-Dec; 50(4): 262-5; discussion 266-7
Artigo em Inglês | IMSEAR | ID: sea-115819
ABSTRACT
BACKGROUND AND

AIMS:

Recognizing the paucity of data regarding echocardiographic studies of Left ventricular (LV) systolic and diastolic function in patients with juvenile rheumatoid arthritis (JRA), a study was carried out to study these parameters in these subjects. SETTINGS, DESIGN AND

METHODS:

Thirty-five patients with JRA and an equal number of age- and sex-matched controls were studied by two-dimensional and Doppler echocardiography.

RESULTS:

Patients with JRA had higher systolic and diastolic blood pressures, resting heart rates, LV systolic (26.9+/-4.3 vs. 22.4 +/- 4.1 mm, p=0.001) and diastolic size (42.3+/-4.6 vs. 35.4+/-3.8 mm, p< 0.001) and volumes. Though ejection fraction (EF) and fractional shortening (FS) were normal, they were lower in those with JRA as compared to controls (EF 62.9+/-4.47 vs. 67.5+/-3.63 %, p< 0.001; FS 36.4+/-4.5 vs. 38.5 +/- 6.87, p=0.2). On Doppler analysis the JRA group had lower peak E velocity, higher peak A velocity, higher A VTI and more prolonged IVRT. Male patients had higher A VTI and IVRT as compared to females. Those with longer duration of disease had larger LV systolic (r=0.517, p=0.01) and diastolic dimension (r=0.40, p=0.05) and lower FS (r=-0.506, p=0.01). Patients with polyarticular JRA had higher E and A VTI as compared to those with systemic or oligoarticular types.

CONCLUSION:

Despite an asymptomatic cardiac status, significant systolic and diastolic functional abnormalities exist in patients with JRA. The duration of the disease, mode of presentation, patient's age and gender have a significant impact on the left ventricular systolic and diastolic functions in patients with JRA.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Artrite Juvenil / Sístole / Pressão Sanguínea / Feminino / Humanos / Masculino / Débito Cardíaco / Estudos de Casos e Controles / Criança / Função Ventricular Esquerda Tipo de estudo: Estudo observacional Idioma: Inglês Revista: J Postgrad Med Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Artrite Juvenil / Sístole / Pressão Sanguínea / Feminino / Humanos / Masculino / Débito Cardíaco / Estudos de Casos e Controles / Criança / Função Ventricular Esquerda Tipo de estudo: Estudo observacional Idioma: Inglês Revista: J Postgrad Med Ano de publicação: 2004 Tipo de documento: Artigo