Acute hemodynamic response to vasodilators in primary pulmonary hypertension.
J Postgrad Med
;
1996 Jan-Mar; 42(1): 7-11
Artigo
em Inglês
| IMSEAR
| ID: sea-115853
ABSTRACT
Acute hemodynamic effects of high flow oxygen (O2) inhalation, sublingual isosorbide dinitrate (ISDN), intravenous aminophylline (AMN) and sublingual nifedipine (NIF) were studied in 32 patients with primary pulmonary hypertension (PPH). In 30 out of 32 patients the basal ratio of pulmonary to systemic vascular resistance (Rp/Rs) was > 0.5 (mean = 0.77 +/- 0.20). Oxygen caused significant decrease in the mean resistance ratio to 0.68 +/- 0.20 (p = 0.005). ISDN, AMN and NIF caused increase in the resistance ratio to 0.79 +/- 0.26; 0.78 +/- 0.26; and 0.80 +/- 0.23 respectively. O2, ISDN, AMN and NIF caused a fall of Rp/Rs in 21 (65.6%), 10 (31.2%), 10(31.2%) and 9(28.1%) patients respectively. Thus, of the four drugs tested high flow O2 inhalation resulted in fall of Rp/Rs in two thirds of patients whereas ISDN, AMN and NIF caused a mean rise in Rp/Rs. One third of patients did respond acutely to the latter three drugs. Acute hemodynamic studies are useful before prescribing vasodilators in patients with PPH since more of the commonly used drugs like ISDN, AMN, NIF could have detrimental hemodynamic responses in some patients. However, great caution should be exercised before performing hemodynamic study as the procedure has definite mortality and morbidity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxigenoterapia
/
Resistência Vascular
/
Vasodilatadores
/
Infusões Intravenosas
/
Idoso
/
Broncodilatadores
/
Feminino
/
Humanos
/
Masculino
/
Administração Sublingual
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
J Postgrad Med
Ano de publicação:
1996
Tipo de documento:
Artigo
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