Clinical and familial correlates of tardive dyskinesia in India and Israel.
J Postgrad Med
;
2004 Jul-Sep; 50(3): 167-72; discussion 172
Artigo
em Inglês
| IMSEAR
| ID: sea-116512
ABSTRACT
BACKGROUND:
Antipsychotic drugs are widely used for the treatment of psychosis, especially schizophrenia. Their long-term use can result at times in serious side-effects such as Tardive Dyskinesia (TD). Since over 80% of schizophrenia sufferers (lifetime prevalence 1%) receive long-term antipsychotic drug treatment, the extent of the problem is potentially large. Increasing age is the most consistently demonstrated risk factor for TD.AIMS:
To assess effect of different clinical factors and demographic variables in India and Israel and sib pair concordance of Tardive Dyskinesia (TD) in India. SETTINGS ANDDESIGN:
The study was conducted simultaneously among Indian and Israelisubjects:
ascertainment was family-based in India and hospital-based in Israel. METHODS ANDMATERIAL:
In India the instruments used were Diagnostic Interview for Genetic Studies (DIGS), Positive and Negative Syndrome Scale (PANSS), Abnormal Involuntary Movement Scale (AIMS), and Simpson Angus Scale (SAS). The last three instruments were also used in Israel. STATISTICALANALYSIS:
Regression analysis and Pearson's correlation. RESULTS ANDCONCLUSIONS:
TD symptoms were present in 40.4% of 151 Israeli subjects and 28.7% of 334 Indian subjects. While age at onset and total scores on PANSS were significant predictors of TD in both the samples, lower scores on the Global Assessment of Functioning Scale (GAF), diagnostic sub-group and male gender were significant predictors among Indians. There was no concordance of TD symptoms among 33 affected sib-pairs from India.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Escalas de Graduação Psiquiátrica
/
Antipsicóticos
/
Feminino
/
Humanos
/
Masculino
/
Adulto
/
Discinesia Induzida por Medicamentos
/
Índia
/
Israel
/
Testes Neuropsicológicos
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
J Postgrad Med
Ano de publicação:
2004
Tipo de documento:
Artigo
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