The role of initial 5-fluorouracil trabeculectomy in primary glaucoma.
J Postgrad Med
;
1994 Oct-Dec; 40(4): 197-201
Artigo
em Inglês
| IMSEAR
| ID: sea-116806
ABSTRACT
Sixty-eight patients with primary glaucoma involving 68 eyes were divided into two groups Group I eyes were subjected to trabeculectomy (n = 38) and Group II eyes underwent trabeculectomy followed by subconjunctival injections of 5-fluorouracil (35 mg) (n = 30). After one year follow-up, Group I eyes exhibited reduction of mean intra-ocular tension from 45.7 mm Hg (pre-operative) to 16 mm Hg; optic disc cupping remained unchanged and 24/38 eyes (63%) were found to have field defects (19/38 i.e. 50% had preoperative field defects.) Group II eyes showed a reduction of mean intra-ocular pressure from 47.3 mmHg to 9.3 mmHg after one year. Mean cup disc ratio was lowered from 0.501 to 0.461 and 17/30 eyes (57%) which had field defects initially continued to exhibit the same. Complications in Group I and II eyes were shallow anterior chamber [8/38 eyes (21%) from Group I and 8/30 eyes (26%) from Group II], posterior synechiae formation in 10/38 eyes (26%) and 8/30 eyes (26%) and cataract progression in 13/38 eyes (34%) and 12/30 eyes (40%) respectively; only Group II eyes had transient superficial keratitis in 9/30 eyes (30%) and thin blebs in 6/30 eyes (20%). The use of 5-fluorouracil after trabeculectomy for primary glaucoma resulted in lowering of intra-ocular pressure, eliminated the need for antiglaucoma medications post-operatively, reduced the galucomatous cup size, and prevented progression of field loss without having a significantly increased complication rate.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Idoso de 80 Anos ou mais
/
Idoso
/
Humanos
/
Trabeculectomia
/
Glaucoma
/
Adulto
/
Fluoruracila
/
Pressão Intraocular
/
Pessoa de Meia-Idade
/
Antimetabólitos
Limite:
Aged80
Idioma:
Inglês
Revista:
J Postgrad Med
Ano de publicação:
1994
Tipo de documento:
Artigo
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