Fungal encephalitis following bone marrow transplantation: clinical findings and prognosis.
J Postgrad Med
;
2008 Jul-Sep; 54(3): 203-5
Artigo
em Inglês
| IMSEAR
| ID: sea-117812
ABSTRACT
BACKGROUND:
Central nervous system fungal infections (FI) are important complications and a cause of mortality in patients who receive hematopoietic stem cell transplantation (HSCT).AIMS:
To study the clinical aspects of fungal encephalitis (FE). SETTINGS ANDDESIGN:
The study was carried out at the HSCT Center of the Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. MATERIALS ANDMETHODS:
Clinical records and autopsy reports from patients submitted to HSCT with a diagnosis of FE.RESULTS:
Twelve patients were diagnosed with FE presenting with lowered level of consciousness, hemiparesis and seizures. We were able to identify two subgroups regarding susceptibility to FE (1) patients with early onset FI and severe leucopenia, and (2) patients with later onset FI with graft-versus-host disease using immunosuppressive drugs. Eleven of the patients died directly due to the neurological complication, all had post-mortem confirmation of the diagnosis of FI.CONCLUSIONS:
These clinical, paraclinical and temporal patterns may provide the opportunity for earlier diagnosis and interventions.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
J Postgrad Med
Ano de publicação:
2008
Tipo de documento:
Artigo
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