Possible biochemical impact of malaria infection in subjects with HIV co-infection in Anambra state, Nigeria.
J Vector Borne Dis
;
2008 Jun; 45(2): 151-6
Artigo
em Inglês
| IMSEAR
| ID: sea-117968
ABSTRACT
BACKGROUND & OBJECTIVES:
The present study was designed to determine possible contributory impact of malaria infection on some biochemical markers in subjects with HIV co-infection in order to know if they are adverse or protective.METHODS:
Participants were recruited at the Voluntary Counseling and Testing Unit, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria and grouped into (i) Malaria and HIV co-infection group (n = 45); and (ii) HIV infected group without concurrent malaria infection (n = 57). Standard laboratory methods were used for the HIV and Plasmodium falciparum antigen screening, malaria parasite density, CD4+ T-cell count, packed cell volume, white blood cell count, serum iron and albumin concentrations.RESULTS:
The results showed that serum iron and albumin were significantly reduced and raised respectively in 'Malaria-HIV co-infection group' compared with 'HIV infection group' (p < 0.05 and p < 0.05). A positive association was observed between age and serum iron concentration in malaria and HIV co-infected group (r = 0.580; p < 0.05) while negative associations were observed between PCV and serum iron (r = - 0.388; p < 0.05) and between CD4+ T-cells and serum iron concentration (r = -0.362; p < 0.05) in malaria and HIV co-infected group. The CD4+ T-cell count, WBC count, PCV were not significantly different between the Malaria-HIV co-infection group and HIV infection group. INTERPRETATION &CONCLUSION:
In the present study serum iron and albumin concentrations were the most sensitive indicators that showed the contributory impact of malaria infection on biochemical index in HIV co-infected subjects. The findings suggest that at the defined stage of HIV infection in the present study, malaria co-infection may moderate the impact of HIV infection on iron metabolism and hepatic synthesis of albumin.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Plasmodium falciparum
/
Feminino
/
Humanos
/
Masculino
/
Albumina Sérica
/
Biomarcadores
/
Comorbidade
/
Infecções por HIV
/
HIV-1
/
Contagem de Linfócito CD4
País/Região como assunto:
África
Idioma:
Inglês
Revista:
J Vector Borne Dis
Assunto da revista:
Parasitology
/
Tropical Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo
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