Molecular pathogenesis of chronic myelogenous leukaemia.
Artigo
em Inglês
| IMSEAR
| ID: sea-119012
ABSTRACT
Chronic myelogenous leukaemia is a clonal neoplasm of the pluripotent haematopoietic stem cell which is characterized in most patients by a consistent cytogenetic abnormality known as the Philadelphia chromosome. This chromosome occurs as a consequence of a reciprocal translocation between the long arms of chromosomes 9 and 22 which results in the creation of a new gene comprising sequences from the c-abl gene on chromosome 9 and the bcr gene on chromosome 22. The protein encoded by this structurally altered hybrid gene differs from the normal c-abl gene product in both molecular weight and in tyrosine kinase activity. It is likely that these alterations in the c-abl gene product play a central role in the pathogenesis of this leukaemia.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Translocação Genética
/
Cromossomo Filadélfia
/
Humanos
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Genes abl
Tipo de estudo:
Estudo de etiologia
Idioma:
Inglês
Ano de publicação:
1992
Tipo de documento:
Artigo
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