Increased cortical excitability with longer duration of Parkinson's disease as evaluated by transcranial magnetic stimulation.
Neurol India
;
2003 Mar; 51(1): 13-5
Artigo
em Inglês
| IMSEAR
| ID: sea-121620
ABSTRACT
Transcranial Magnetic Stimulation (TMS) was used to evaluate the cortical excitability and central motor pathways in Parkinson's disease (PD) and correlate with severity and duration of disease. 19 cases of PD and 13 controls were enrolled. The threshold intensity (TI), cortical latency (CL), central conduction time (CCT), motor evoked potential amplitude (MEP) obtained with TMS were correlated with Hoehn and Yahr and duration of disease. The threshold intensity (TI) was significantly lower in patients of PD than controls. The TI in patients with PD was 53.16-/+8.4% patients and 67.1-/+21.6% in controls (p<0.05). This strongly correlated with duration of disease, TI being lower in patients with disease duration more than 5 years. There was no difference in the other TMS parameters - CL, CCT, MEP between patients and controls. Our study revealed increased excitability in PD which was related to longer duration of disease.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Doença de Parkinson
/
Índice de Gravidade de Doença
/
Idoso
/
Humanos
/
Córtex Cerebral
/
Estimulação Elétrica
/
Estimulação Magnética Transcraniana
/
Pessoa de Meia-Idade
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
Neurol India
Ano de publicação:
2003
Tipo de documento:
Artigo
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