Cerebral perfusion pressure management of severe diffuse head injury: effect on brain compliance and intracranial pressure.
Neurol India
;
2004 Mar; 52(1): 67-71
Artigo
em Inglês
| IMSEAR
| ID: sea-121721
ABSTRACT
BACKGROUND:
Cerebral perfusion pressure management (CPPM) is an accepted modality of treatment of severe diffuse head injury (SDHI). However, CPPM has the potential to cause transcapillary exudation in the presence of a disrupted blood brain barrier and can lead to further increase of intracranial pressure (ICP) and worsening of compliance.AIMS:
This study attempts to evaluate the effect of both transient and prolonged changes in cerebral perfusion pressure (CPP) on ICP and cerebral compliance as measured by the Pressure Volume Index (PVI), and to correlate changes in PVI with outcome at 12 months using the Glasgow Outcome Score. SETTINGS ANDDESIGN:
Prospective study in a neurosurgical ICU. MATERIAL ANDMETHODS:
Twenty-seven SDHI patients managed using standard protocol to maintain CPP above 70 mmHg. Mean arterial pressure (MAP), ICP and CPP were monitored every half-hour. Daily monitoring of the PVI and ICP was done before, and after the induced elevation of MAP using IV Dopamine infusion. The relationship between CPP, MAP, ICP, PVI and outcome was evaluated. STATISTICAL ANALYSIS USED The paired and independent samples T-test, and the Pearson correlation coefficient.RESULTS:
CPPM rarely leads to progressive rise in ICP. Maintaining CPP above 70mmHg does not influence ICP or PVI. Transient elevations in CPP above 70mmHg may produce a small rise in ICP. Trend of change in PVI influenced outcome despite similar ICP and CPP.CONCLUSION:
Elevating the CPP above 70mmHg does not either reduce the ICP or worsen the compliance. Monitoring changes in compliance should form an integral part of CPPM.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Pressão Sanguínea
/
Encéfalo
/
Feminino
/
Humanos
/
Masculino
/
Pressão Intracraniana
/
Circulação Cerebrovascular
/
Estudos Prospectivos
/
Resultado do Tratamento
Tipo de estudo:
Guia de Prática Clínica
/
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Neurol India
Ano de publicação:
2004
Tipo de documento:
Artigo
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