Effect of erythromycin and cisapride on emptying of the vagally denervated intrathoracic stomach.
Artigo
em Inglês
| IMSEAR
| ID: sea-124347
ABSTRACT
BACKGROUND:
Subsequent to esophagectomy and reconstruction among patients with esophageal cancers, the intrathoracic denervated stomach acts as a passive conduit without peristalsis.OBJECTIVE:
The study was designed to assess the impact of two prokinetic drugs viz. erythromycin and cisapride on the emptying of vagally denervated intrathoracic stomach.METHODS:
Twenty consecutive patients of carcinoma esophagus, who had undergone one stage transhiatal oesophagectomy with cervical esophagogastrostomy and were disease free at three months postoperative follow-up, were included in the study. These patients were randomised into two groups of ten each. The patients in group A received erythromycin, while patients in group B received cisapride. The gastric emptying was studied by scintigraphy, using a standard test meal containing 99m Tc sulphur colloid labelled 'IDLIS' [rice based radio labelled food] before and after the drug treatment.RESULTS:
The pre and post treatment mean gastric half emptying time of the patients in the erythromycin group was 52.6 min and 49.7 min (p > 0.1) and in cisapride group it was 53.76 and 26.4 min respectively (p < 0.05). Intergroup comparison of the difference was not statistically significant.CONCLUSION:
Cisapride is an effective prokinetic agent in the treatment of gastric stasis of the vagally denervated intrathoracic stomach.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Estômago
/
Vagotomia
/
Fármacos Gastrointestinais
/
Feminino
/
Humanos
/
Masculino
/
Neoplasias Esofágicas
/
Eritromicina
/
Esofagectomia
/
Estatísticas não Paramétricas
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Ano de publicação:
2002
Tipo de documento:
Artigo
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