Non-familial juvenile polyposis with histological evidence of adenomatous transformation.
Artigo
em Inglês
| IMSEAR
| ID: sea-124939
ABSTRACT
A 14-year-old male presented with abdominal pain, diarrhoea and a sensation of something prolapsing through the anus during defecation, and was found to have diffuse colonic polyposis. There was no evidence of mucocutaneous hyperpigmentation and family history was negative, suggesting a diagnosis of non-familial juvenile polyposis. Histological analysis of multiple endoscopic biopsies showed features typical of juvenile or retention type (hamartomatous) lesions dilated cystic glands lined by mucocus-secreting epithelium and prominent, inflamed and congested lamina propria. However, admixed with these features, focal areas of atypical adenomatous changes were recognized. Even the intervening normal-looking colonic mucosa showed some dysplastic changes. These findings indicate that hamartomatous and atypical adenomatous epithelial changes can co exist in non-familial juvenile polyposis and the latter may confer a risk of malignant transformation in this otherwise non-neoplastic disease.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Masculino
/
Transformação Celular Neoplásica
/
Adolescente
/
Neoplasias do Colo
/
Pólipos Adenomatosos
/
Polipose Intestinal
/
Hamartoma
/
Índia
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2004
Tipo de documento:
Artigo
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