Hypotensive property of Plantago major Linn

ABSTRACT

50 per cent water-alcohol soluble extract of Plantago major Linn, from Rangoon, Kalaw and Taunggyi was tested for hypotensive action on anaesthetized normotensive dogs. Early trials with the water-alcohol soluble extract in a dose of 125 mg/kg given intravenously was found to produce a fall in arterial blood pressure of 20-40 mm Hg. Further fractionation of the extract was carried out and screened for hypotensivity activity. The fraction designated F -7 produced a fall in the arterial blood pressure which was sustained up to 1 hr.