Enterically transmitted Non-A,Non B, hepatitis immunity in Rhesus Cynomolgus monkeys (Macaca mulatta & Macaca fascicularis)

ABSTRACT

An exoerimental model of enterically transmitted non-A, non-B hapatitis was established in rhesus and cynomolgus monkeys (Macaca mulatta and Macaca fascicularis). Two monkeys previously infected with 10 per cent pooled stool suspensions of Myanmar patients with well-defined enterically transmitted non-A, non-B, hepatitis and three virgin control monkeys were infected simultaneously with pools of stool suspensions from the first-passage. None of the two previously infected monkeys developed signs of hepatitis. All the control virgin monkeys exhibited hepattis as evident by sharp rise in serum aminotransfrases and pathological changes of acute hepatitis in liver biopsies. These findings document the establishment of immunity after infection with enterically transmitted non-A, non-B hepatitis virus in rhesus and cynomolgus monkeys.