Individualized Therapy and Pharmacogenetic Test

ABSTRACT

Variability of drug response and toxic adverse effects are primarily responsible for the failure of drug therapy. Individual variation in genetic composition in regulating pharmacokinetic and pharmacodynamic processes, such as genes of drug metabolizing enzymes and genes of receptor or enzyme of drug response is critically important in determining drug efficacy. Pharmacogenetic testing will enable selection of appropriate drugs from the beginning, avoiding the drugs that could cause serious adverse events and assortment of alternative drugs to enhance therapeutic efficacy and minimize the illness.