Prevention of Epidural Morphine – induced Pruritus and Nausea – Vomiting by Intranuscular nalbuphine 10 mg. in Caesarean Section patients.

ABSTRACT

Background: The  common  side  effects  of  epidural  morphine  are  prurits  discomfort.Objective: To  test  the  hypothesis  that  nalbuphine  can  prevent  epidural  morphine-induced  pruritus  and  nausea vomiting.Design: Randomized  controlled  trial.Setting: Srinagarind  hospital,  Khon  kaen  university.Subjects: Sixty – four  caesarean patients (ASA 1-2) were randomly assingned  into 2 groups.Intervention Epidural  anesthesia with 2% lidocaine with adrenaline 1200,000 18-20 ml. plus morphine 5 mg. was performed  in  every patient.  After delivery  of  the  babies  patients  in  group 1 (n=32) received  NSS 1 ml. and  patients  in  group 2 (n=32)  received  nalbuphine  10 mg.  intramuscularly.Measurements Side  effects  of  epidural  morphine  were  observed  for  a  24 hour  period. Results: The  incidence  of  pruritus  and  nausea – vomiting were  not  different  significantly  between  the  two  groups.  No  respiratory  depression  occurred.Conclusion: We  concluded  that  nalbuphine  10 mg.  given  by  intramuscular  injection  could  not  prevent  epidural  morphine-induced  pruritus  and  nausea-vomiting.Key  words Epidural  morphine,  Side  effects,  Prevention, Nalbuphine.