Lipid profiles in cerebral and hepatic tissues of wistar rats during chronic phosphamidon toxicity.

ABSTRACT

The possibility of alterations in function of lipids in structural components of membranes such as storage, protective coating on the surface, cell recognition, and tissue immunity during phosphamidon stress, prompted the present investigation. Specifically chosen doses of phosphamidon, viz, acute dose (AD) (1/2 LD50, 6.63 mg/kg body wt/day), and subacute dose (ASD) (1/3 LD50; 0.10 mg/kg body wt/day) were administered to male Wistar rats orally by gavage. After the stipulated treatment period, brain and liver from these rats were examined for lipid profiles such as cholesterol triglycerides and phospholipids, using standard biochemical procedures. An increase in lipid peroxidation in conjunction with reduced levels of lipid profiles indicated that the lipid profiles were variously affected depending on different altered chemical reactons in the tissues of animal under stress. The study shows that induced lipid peroxidation was on par with the reduced levels of lipid profiles, indicating that the lipid profiles under continued daily dosing of phosphamidon could generate free radicals, in spite of elevation in the levels of antioxidants, or antioxidant enzyme activity, or both.