Evaluation of anti-allergic activity of gossypin and suramin in mast cell-mediated allergy model.
Indian J Biochem Biophys
;
2010 Apr; 47(2): 90-95
Artigo
em Inglês
| IMSEAR
| ID: sea-135249
ABSTRACT
The mast cell-mediated allergic reactions are involved in many allergic diseases, such as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells initiates the process of degranulation, resulting in the release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of gossypin (a biflavonoid) and suramin (a synthetic polysulphonated naphtylurea) on the mast cell-mediated allergy model, and studied the possible mechanism of their action. Both gossypin and suramin inhibited (P<0.001) compound 48/80-induced systemic anaphylaxis reactions, antiprurities (P<0.001) and reduced the histamine release in rats. Further, both showed significant (P<0.001) protection against rat peritoneal mast cells activated by compound 48/80. Thus, our findings provide evidence that gossypin and suramin inhibit mast cell-derived allergic reactions.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Suramina
/
Flavonoides
/
Líquido Ascítico
/
Líquido da Lavagem Broncoalveolar
/
P-Metoxi-N-metilfenetilamina
/
Antialérgicos
/
Modelos Animais de Doenças
/
Liberação de Histamina
/
Hipersensibilidade
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2010
Tipo de documento:
Artigo
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