Hepatoprotective activity of leaves of Zanthoxylum armatum DC in CCl4 induced hepatotoxicity in rats.
Indian J Biochem Biophys
;
2010 Apr; 47(2): 124-127
Artigo
em Inglês
| IMSEAR
| ID: sea-135256
ABSTRACT
Zanthoxylum armatum DC (Rutaceae) is extensively used in indigenous system of medicine as a tonic, carminative, stomachic and anthelmintic. In the present study, the hepatoprotective activity of the leaves ethanolic extract of Z. armatum (EEZA) was evaluated in CCl4-induced hepatotoxicity in rats. The extract at a dose of 500 mg/kg registered a significant decrease in the levels of serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALKP), and serum bilurubin (SBLN) and liver inflammation, which was supported by histopathological studies on liver, thus exhibited a significant hepatoprotective activity. The phytochemical screening of defatted ethanolic extract showed the presence of sterols, alkaloids, flavonoids, and reducing sugars.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Feminino
/
Masculino
/
Tetracloreto de Carbono
/
Extratos Vegetais
/
Ratos Wistar
/
Folhas de Planta
/
Zanthoxylum
/
Etanol
/
Fígado
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2010
Tipo de documento:
Artigo
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