DNA degradation by aqueous extract of Aloe vera in the presence of copper ions.
Indian J Biochem Biophys
;
2010 June; 47(3): 161-165
Artigo
em Inglês
| IMSEAR
| ID: sea-135261
ABSTRACT
The plant Aloe vera has long been used in medicine, as dietary supplements and for cosmetic purposes. Aloe vera extracts are a rich source of polyphenols, such as aloin and aloe emodin and have shown a wide range of pharmacological properties, including anti-inflammatory and anti-cancer properties. The bioactive component aloe emodin has been reported to induce apoptosis in various cancer cell lines. Many of the biological activities of Aloe vera have been attributed to its antioxidant properties. However, most plant-derived polyphenols that are also present in Aloe vera may exhibit pro-oxidant properties either alone or in the presence of transition metals, such as copper. Previous reports from this laboratory have implicated the pro-oxidant action as one of the mechanisms for their anti-cancer properties. In the present paper, we show that aqueous extract of Aloe vera is also able to cause DNA degradation in the presence of copper ions. Further, the extract is also able to reduce Cu(II) to Cu(I) and generate reactive oxygen species, such as superoxide anion and hydroxyl radicals in a dose-dependent manner, which correlates with ability of the extract to cause DNA breakage. Thus, the study shows that in addition to antioxidant activity, Aloe vera extract also possess pro-oxidant properties, leading to oxidative DNA breakage.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fenóis
/
Plasmídeos
/
Flavonoides
/
Bovinos
/
Oxidantes
/
Cobre
/
Aloe
/
Quebras de DNA
/
Fragmentação do DNA
/
Polifenóis
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2010
Tipo de documento:
Artigo
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