MsbA ATP-binding cassette (ABC) transporter of E. coli: Structure and possible flippase mechanism.
Indian J Biochem Biophys
;
2011 Feb; 48(1): 7-13
Artigo
em Inglês
| IMSEAR
| ID: sea-135294
ABSTRACT
ATP-binding cassette (ABC) transporters utilize the energy present in cellular ATP to drive the translocation of structurally diverse set of solutes across the membrane barriers of eubacteria, archaebacteria and eukaryotes. In bacteria, these transporters are considered to be important virulence factors because they play role in nutrient uptake and in the secretion of toxins. The advances in structural determination and functional analysis of bacterial transporters have greatly increased our understanding of the mechanism of transport of these ABC transporters. Although progress in the field of structural biology has been made with the prokaryotic family members, it is likely that eukaryotic transporters will utilize the same mechanisms for translocation process. In this review, we summarize the function of the known MsbA ABC transporters in E. coli and mechanistic insights from structural and possible flippase mechanism studies.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Proteínas de Membrana Transportadoras
/
Proteínas de Bactérias
/
Transporte Biológico
/
Trifosfato de Adenosina
/
Estrutura Terciária de Proteína
/
Estrutura Secundária de Proteína
/
Transportadores de Cassetes de Ligação de ATP
/
Dimerização
/
Proteínas de Transferência de Fosfolipídeos
/
Escherichia coli
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2011
Tipo de documento:
Artigo
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