Cholera toxin: A paradigm of a multifunctional protein.
Artigo
em Inglês
| IMSEAR
| ID: sea-135369
ABSTRACT
Cholera toxin (CT) was discovered exactly half a century ago by S.N. De. We have come a long way since this epoch-making discovery. Retrospectively, science had to wait a long time since Koch’s prediction of the existence of a toxin, and its actual discovery by De. CT is not just another enterotoxin that causes the signs and symptoms of the dreaded disease, cholera. It is unique in many respects, starting from its structure to its functions. CT is a multifunctional protein that is capable of influencing the immune system in many ways. It not only has remarkable adjuvant properties, but also acts as an anti-inflammatory agent, by modulating specific signal transduction pathways. Its immunomodulatory properties can be harnessed for treatment of various autoimmune disorders, and have shown great promise in the area of immunotherapeutics. CT can truly be considered as a paradigm of a multifunctional protein.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Doenças Autoimunes
/
Humanos
/
Vacinas contra Cólera
/
Difosfato de Adenosina
/
Toxina da Cólera
/
Fatores Imunológicos
/
Imunoterapia
/
Animais
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2011
Tipo de documento:
Artigo
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