Neutrophils to lymphocyte ratio as a screening tool for swine influenza.
Artigo
em Inglês
| IMSEAR
| ID: sea-135773
ABSTRACT
Background & objectives:
During an outbreak of influenza like illness throat swab culture and virus isolation are done to identify causal virus, and it may cause a significant delay in diagnosis and isolation. There is a need to determine a sensitive laboratory parameter which could play a major role in identifying H1N1 infection among patients presenting with influenza like symptoms. We undertook this study to determine a laboratory parameter to identify swine influenza infection amoung patients presenting with influenza like symptoms while awaiting throat swab culture and virus isolation reports.Methods:
This retrospective study was conducted on patients presenting to A.P TB and Chest Hospital, Hyderabad, with swine influenza symptoms during September-October 2009. They were divided into swine flu positive (SW+) and swine flu negative (SW-) groups, based on their throat swab culture reports and laboratory data. Neutrophils to lymphocyte (N/L) ratio was calculated for every patient and also mean N/L ratio for two groups. Mean WBC count was also noted for both groups.Results:
There were 55 patients in each group. The WBC count in SW+ group varied from 3000 to 10600 cells/mm3 (mean 5714), while in SW- group it varied from 4500 to 14300 cells/mm3 (10252). The N/L ratio was less than two for 92.7 per cent of patients in SW+ group and for 3.63 per cent patients in SW- group. N/L ratio < 2 as an indicator for swine flu had a sensitivity of 92.7 per cent and specificity of 96.36 per cent. It has a positive predictive value of 96.22 per cent and a negative predictive value of 92.8 per cent. Interpretation &conclusions:
N/L < 2 along with a decrease in WBC count can be used as a screening tool in patients presenting with influenza like symptoms, while awaiting throat swab culture reports for confirmation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Linfócitos
/
Estudos Retrospectivos
/
Sensibilidade e Especificidade
/
Adolescente
/
Adulto
/
Influenza Humana
/
Vírus da Influenza A Subtipo H1N1
/
Índia
/
Contagem de Leucócitos
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Estudo de rastreamento
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2011
Tipo de documento:
Artigo
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