Helicobacter pylori vaccine: mucosal adjuvant & delivery systems.
Artigo
em Inglês
| IMSEAR
| ID: sea-135873
ABSTRACT
Vaccination, especially mucosal vaccination, is considered to be effective in the management of Helicobacter pylori infections. However, most antigens alone cannot induce immune responses when administered mucosally and need to be co-administered with adjuvants or delivery systems. The current research on the mucosal adjuvant and delivery systems of vaccine against H. pylori, including advantages and disadvantages, mechanisms and applications is discussed in this review. Mutants of cholera toxin (CT) and the heat labile enterotoxin of Escherichia coli (LT), CpG oligodeoxynucleotides, biocompatible and biodegradable polymers, and live attenuated bacterial vectors may be promising adjuvant and delivery systems for H. pylori vaccine.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Portadores de Fármacos
/
Vacinas Bacterianas
/
Adjuvantes Imunológicos
/
Toxina da Cólera
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Enterotoxinas
/
Animais
/
Mucosa
Idioma:
Inglês
Ano de publicação:
2009
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS