Derris scandens benth extract radiosensitizes HT-29 colon cancer cells.
Artigo
em Inglês
| IMSEAR
| ID: sea-136479
ABSTRACT
Objective:
To evaluate the radiosensitizing potential of Derris scandens extract in a human colon cancer cell model.Methods:
The radiosensitizing effect of D., scandens extract on human colon cancer cells (HT-29) and non-cancerous human retinal epithelial cells (RPE) was determined by cell survival and micronuclei analysis after irradiation. Cell cycle distribution was analyzed by a flow cytometer.Results:
D. scandens extract powerfully increases the radiosensitivity of HT-29 cells, but is less toxic and does not affect the radiosensitivity of RPE cells. Furthermore, the extract was found to reduce radiation-induced G2/M phase arrest in HT-29 cells, but not in RPE cells.Conclusion:
D., scandens extract may have potential as a radiosensitizer for cancer treatment.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Idioma:
Inglês
Ano de publicação:
2011
Tipo de documento:
Artigo
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