Serotonin syndrome with rhabdomyolysis: A case report and recommended prevention.

ABSTRACT

Serotonin syndrome is a severe but preventable adverse drug reaction. This syndrome is rare and usually underrecognized. It is resulted from the excessive serotonin receptor stimulation, mostly by combination of serotonergic agents. The clinical triads are altered mental status, autonomic dysfunction and neuromuscular abnormalities. Occasionally, severe cases of serotonin syndrome are complicated by rhabdomyolysis and other potentially life-threatening conditions. In this report, we describe a 22-year-old man presenting with serotonin syndrome and rhabdomyolysis from serotonergic drug interaction. In addition, recommendation of preventive strategies is included.