Low-cost assays for monitoring HIV infected individuals in resource-limited settings.
Artigo
em Inglês
| IMSEAR
| ID: sea-137344
ABSTRACT
Use of a combination of CD4 counts and HIV viral load testing in the management of antiretroviral therapy (ART) provides higher prognostic estimation of the risk of disease progression than does the use of either test alone. The standard methods to monitor HIV infection are flow cytometry based for CD4+ T cell count and molecular assays to quantify plasma viral load of HIV. Commercial assays have been routinely used in developed countries to monitor ART. However, these assays require expensive equipment and reagents, well trained operators, and established laboratory infrastructure. These requirements restrict their use in resource-limited settings where people are most afflicted with the HIV-1 epidemic. With the advent of low-cost and/or low-tech alternatives, the possibility of implementing CD4 count and viral load testing in the management of ART in resource-limited settings is increasing. However, an appropriate validation should have been done before putting them to use for patient testing.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Humanos
/
Monitorização Imunológica
/
Infecções por HIV
/
HIV-1
/
Progressão da Doença
/
Contagem de Linfócito CD4
/
Carga Viral
/
Países em Desenvolvimento
Tipo de estudo:
Avaliação Econômica em Saúde
/
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2011
Tipo de documento:
Artigo
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