Improving height velocity in boys with constitutional delayed growth and puberty (CDGP) by using oral testosterone undecanoate.

ABSTRACT

Treatment with oral testosterone undecanoate (40 mg daily) in 9 boys diagnosed as having constitutional delayed growth and puberty (CDGP) was studied. The mean chronological age was 12.1+ 1.7 years and the mean duration of treatment was 0.7+ 0.3 year. The height velocity was increased from 3.9+ 2.1 cm per year before treatment up to 8.1+ 2.3 cm per year treatment (p=0.003). However, the predicted adult height was not different between pre and post treatment. Eighty-nine percent of children reached the pubertal testicular size after treatment. Therefore, oral testosterone undecanoate was proved to be effective to improve height velocity but the predicted adult height in CDGP boys.