Dissolution of imported and locally-made terfenadine tablet.

ABSTRACT

Terfenadine, an effective histamine H1- antagonist, is a popular in Thailand. Both imported and locally-made brands are available in the market. This study was performed to prove the general characteristics and the dissolution profile of one imported terfenadine tablet and five locally-made brands. The tablet from each brand were uniform in weight, thickness and diameter. The dissolution profile of the other three locally-made products do not reach the standard dissolution profile.