Insulin Dependent Diabetes Mellitus (IDDM): Clinical data and HLA antigen.

ABSTRACT

We studied 34 cases of IDDM attending diabetic clinic at Siriraj Hospital from May to November 1988. The study covered background personal, clinical history, diabetic control, diabetic knowledge, socioeconomic status, frequency and cause of admission. HAL antigen was performed in 20 cases. The age of IDDM ranged from 4 to 22 years with peak age at 11 to 15 years. Male to female ratio was 11 Majority had low socioeconomic status. Total admission of 26 IDDM were 57 occasions in the part 10 years, consisted of diabetic ketoacidosis (DKA), poor control and infections, malnutrition and hypoglycemia in 29, 20, 4 and 4 episodes respectively. However there was no statistically significant between socioecomic status and frequency of DKA. HLA DR3 is the most important genetic marker in IDDM. HLA DR4 alone was not significantly increased in IDDm, but is combination with DR3 and DR4 was important genetic marker in Thai IDDM. However there was no relationship between HLA DR3 and/or HLA DR4 and DKA. However further investigation should be done to clarify the etiologic factor of Thai IDDM.