Effect of deferiprone on urinary zinc excretion in multiply transfused children with thalassemia major.
Indian Pediatr
;
2005 Feb; 42(2): 150-4
Artigo
em Inglês
| IMSEAR
| ID: sea-13857
ABSTRACT
A prospective multi-centric study was conducted to determine if iron-chelating agent deferiprone also chelates zinc. Twenty four-hour urinary zinc levels were compared in multiply transfused children with thalassemia major not receiving any chelation therapy (Group A, n = 28), those receiving deferiprone (Group B, n = 30) and age and sex-matched controls of subjects in Group B (Group C, n = 29) by a colorimetric method. The 24-hour mean urinary excretion of zinc was significantly higher in Group B than in the other two groups indicating that deferiprone chelates zinc.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Piridonas
/
Fatores de Tempo
/
Zinco
/
Transfusão de Sangue
/
Feminino
/
Humanos
/
Masculino
/
Criança
/
Pré-Escolar
/
Quelantes de Ferro
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2005
Tipo de documento:
Artigo
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