Outcome of optical penetrating keratoplasties at a tertiary care eye institute in Western India.
Indian J Ophthalmol
;
2012 Jan; 60(1): 15-21
Artigo
em Inglês
| IMSEAR
| ID: sea-138783
ABSTRACT
Aim:
To study the indications, risk factors, postoperative course, and long-term survival of corneal transplants done for optical purposes.Design:
Retrospective case series. Materials andMethods:
Data were obtained by reviewing the records of 181 patients operated at our institute (H.V. Desai Eye Hospital) between October 2005 and October 2007 for optical penetrating keratoplasty. Patients with less than one year of follow up, pediatric cases, therapeutic, tectonic, and lamellar keratoplasties were excluded. Kaplan Meier survival analysis was used to calculate median survival time of grafts and to see correlation between nine variables viz. age, gender, corneal vascularization, previous failed grafts, previous Herpes Simplex keratitis, post-perforation corneal scars, donor tissue quality, graft size, type of surgery and follow-up. These variables were also used for univariate and multivariate analysis using Cox Proportional Hazard Regression Modeling.Results:
Median survival of the cohort was 27 months (95% confidence interval 20.47-33.52). One- and two-year survival rates were 65% and 52.5%, respectively. Median survival was significantly lower in poor prognosis cases (14 months) than good prognosis cases (27 months, P = 0.0405). Graft survival was lower in vascularized corneas (18.55 months, P = 0.030) and in post-perforation corneal scars (17.96 months, P = 0.09, borderline significance). Multivariate analysis showed that the same factors were predictive of graft failure.Conclusion:
Long-term survival of grafts at our center is different from centers in western world. More high-risk cases, paucity of excellent quality donor corneas, and differences in patient profile could be the contributory factors.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Complicações Pós-Operatórias
/
Fatores de Tempo
/
Feminino
/
Humanos
/
Masculino
/
Acuidade Visual
/
Modelos de Riscos Proporcionais
/
Incidência
/
Estudos Retrospectivos
/
Seguimentos
Tipo de estudo:
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Ophthalmol
Ano de publicação:
2012
Tipo de documento:
Artigo
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