Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy.
Indian J Hum Genet
;
2009 Jan; 15(1): 3-8
Artigo
em Inglês
| IMSEAR
| ID: sea-138862
ABSTRACT
Gene analysis of tumor associated antigens revealed that tumor antigens are all normal gene product. Inducing tumor reactive cytotoxic T lymphocytes (CT) in the patients is same as inducing autoimmunity in the patients. Immunosuppressive cytokine interleukin-10 (IL-10) plays an important role in maintaining homeostasis or tolerance. To break the tumor tolerance, blocking and IL-10 secretion or intervention in the pathways of IL-10 gene activation is indeed important.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pacientes
/
Humanos
/
Linfócitos T Citotóxicos
/
Autoimunidade
/
Interleucina-10
/
Vacinas Anticâncer
/
Homeostase
/
Imunoterapia
/
Antígenos de Neoplasias
/
Neoplasias
Idioma:
Inglês
Revista:
Indian J Hum Genet
Ano de publicação:
2009
Tipo de documento:
Artigo
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