Absence of mutations in GJB2 (Connexin-26) gene in an ethnic group of southwest Iran.
Indian J Hum Genet
;
2009 Jan; 15(1): 9-12
Artigo
em Inglês
| IMSEAR
| ID: sea-138863
ABSTRACT
BACKGROUND:
The common GJB2 gene mutation (35delG) has been previously reported from Iranian patients that were affected with nonsyndromic autosomal recessive deafness. We, therefore, for the first time, investigated the prevalence and frequency of the GJB2 gene mutation in the Iranian deaf population with Arabian origins. MATERIALS ANDMETHODs:
We amplified and sequenced the entire coding sequence of the GJB2 gene from 61 deaf patients and 26 control subjects.RESULT:
None of the analyzed samples revealed deafness-associated mutation.CONCLUSION:
This finding differs from several reports from Iran as we have focused on the GJB2 gene that possesses various mutations as the cause of congenital recessive deafness.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
DNA
/
Etnicidade
/
Reação em Cadeia da Polimerase
/
Deleção de Genes
/
Conexinas
/
Árabes
/
Perda Auditiva Neurossensorial
/
Irã (Geográfico)
/
Mutação
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Hum Genet
Ano de publicação:
2009
Tipo de documento:
Artigo
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