Y-haplotypes and idiopathic male infertility in an Indian population.
Indian J Hum Genet
;
2009 Jan; 15(1): 19-22
Artigo
em Inglês
| IMSEAR
| ID: sea-138865
ABSTRACT
Infertility being a multifactorial disorder, both genetic and environmental factors contribute to the etiology of infertile phenotype. Chromosomal anomalies and Y-microdeletion are the established genetic risk factors of male infertility. Y-haplotypes has been found as risk factor for male infertility in certain populations, though in certain others no association has been reported, suggesting a population-specific association of these variations with male infertility. In a case-control study, 165 azoo-/oligospermic patients and 200 controls were haplotyped for certain Y-haplogroups for a possible association with idiopathic male infertility in an Indian population. Analysed Y-haplogroups showed no association with infertile phenotype. Thus this genetic factor is not a risk for infertility in the studied Indian population but that does not rule out the possibility of any of them, to be a risk in other populations.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
População
/
Cromossomo Y
/
Haplótipos
/
Humanos
/
Masculino
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Índia
/
Infertilidade Masculina
Tipo de estudo:
Estudo observacional
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Hum Genet
Ano de publicação:
2009
Tipo de documento:
Artigo
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