Association of CYP3A5*3 polymorphism with development of acute leukemia.
Indian J Hum Genet
;
2011 Sept; 17(3): 175-178
Artigo
em Inglês
| IMSEAR
| ID: sea-138959
ABSTRACT
BACKGROUND:
CYP3A5 was observed to be an important genetic contributor to inter individual differences in CYP3A-dependent drug metabolism in acute leukemic patients. Loss of CYP3A5 expression was mainly conferred by a single nucleotide polymorphism at 6986A>G (CYP3A5*3). We investigated the association between CYP3A5*3 polymorphism and acute leukemia. MATERIALS ANDMETHODS:
Two hundred and eighty nine acute leukemia cases comprising of 145 acute lymphocytic leukemia (ALL), 144 acute myeloid leukemia and 241 control samples were analyzed for CYP3A5*3 polymorphism using PCR-RFLP method. Statistical analysis was performed with SPSS version (15.0) to detect the association between CYP3A5*3 polymorphism and acute leukemia.RESULTS:
The CYP3A5*3 polymorphism 3/3 genotype was significantly associated with acute leukemia development (χ2- 133.53; df-2, P 0.000). When the data was analyzed with respect to clinical variables, mean WBC, blast % and LDH levels were increased in both ALL and AML cases with 3/3 genotype. The epidemiological variables did not contribute to the genotype risk to develop either AML or ALL.CONCLUSION:
The results suggest that the CYP3A5*3 polymorphism might confer the risk to develop ALL or AML emphasizing the significance of effective phase I detoxification in carcinogenesis. Association of the polymorphism with clinical variables indicate that the 3/3 genotype might also contribute to poorer survival of the patients.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Leucemia Mieloide Aguda
/
Anticarcinógenos
/
Citocromo P-450 CYP3A
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Idioma:
Inglês
Revista:
Indian J Hum Genet
Ano de publicação:
2011
Tipo de documento:
Artigo
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